The Role of Kisspeptin in Discrimination Between Missed Miscarriage and Intrauterine Viable Pregnancy

Asmaa Abdulsattar Hassan; Esraa Abdulkareem Mohammed

doi:10.54133/ajms.v8i2.2012

Authors

Asmaa Abdulsattar Hassan Iraqi Board for Medical Specializations, Department of Gynecology and Obstetrics, Azadi Teaching Hospital, Kirkuk, Iraq
Esraa Abdulkareem Mohammed Department of Gynecology and Obstetrics, College of Medicine, University of Kirkuk, Kirkuk, Iraq https://orcid.org/0000-0002-8425-6040

DOI:

https://doi.org/10.54133/ajms.v8i2.2012

Keywords:

β-hCG, Kisspeptin, Miscarriage, Viable pregnancy

Abstract

Background: Missed miscarriage is a common complication, which affects 15% of pregnancies. The loss of a pregnancy is distressing for women and their partners. A biomarker for evaluation of the viability of gestation is kisspeptin because of the role of this marker is the regulation of trophoblast function and placentation. Kisspeptin plays a significant role in implantation and decidualization. Objective: To evaluate the role of serum kisspeptin in discrimination between missed miscarriage and viable intrauterine pregnancy. Methods: A case-control study was conducted in the Department of Obstetrics and Gynecology at Azadi Teaching Hospital, Kirkuk. It included 92 women with singleton pregnancies; they were divided into 2 groups: The case group included 45 pregnant women who presented with missed miscarriage, and the control group included 47 women with viable singleton pregnancy. Tests for kisspeptin level and β-hCG level were done for both groups. Results: Kisspeptin and β-hCG values were significantly lower in miscarriage cases compared to the control group. The optimal kisspeptin level for the discrimination between miscarriage and viable intrauterine pregnancies was 53.3 ng/l. Hence, a kisspeptin level < 53.3 ng/l is a predictor for missed miscarriage. The optimal β-hCG level for the discrimination between miscarriage and viable intrauterine pregnancies was 8642.2 ng/l. The correlation between kisspeptin and β-hCG levels was a significant positive. Conclusions: Kisspeptin and β-hCG levels are more sensitive and specific in predicting early missed miscarriage. They represent non-invasive, early, and excellent predictors of missed miscarriage, which can be used if confirmed by further studies.

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