The Role of Kisspeptin in Discrimination Between Missed Miscarriage and Intrauterine Viable Pregnancy
DOI:
https://doi.org/10.54133/ajms.v8i2.2012Keywords:
β-hCG, Kisspeptin, Miscarriage, Viable pregnancyAbstract
Background: Missed miscarriage is a common complication, which affects 15% of pregnancies. The loss of a pregnancy is distressing for women and their partners. A biomarker for evaluation of the viability of gestation is kisspeptin because of the role of this marker is the regulation of trophoblast function and placentation. Kisspeptin plays a significant role in implantation and decidualization. Objective: To evaluate the role of serum kisspeptin in discrimination between missed miscarriage and viable intrauterine pregnancy. Methods: A case-control study was conducted in the Department of Obstetrics and Gynecology at Azadi Teaching Hospital, Kirkuk. It included 92 women with singleton pregnancies; they were divided into 2 groups: The case group included 45 pregnant women who presented with missed miscarriage, and the control group included 47 women with viable singleton pregnancy. Tests for kisspeptin level and β-hCG level were done for both groups. Results: Kisspeptin and β-hCG values were significantly lower in miscarriage cases compared to the control group. The optimal kisspeptin level for the discrimination between miscarriage and viable intrauterine pregnancies was 53.3 ng/l. Hence, a kisspeptin level < 53.3 ng/l is a predictor for missed miscarriage. The optimal β-hCG level for the discrimination between miscarriage and viable intrauterine pregnancies was 8642.2 ng/l. The correlation between kisspeptin and β-hCG levels was a significant positive. Conclusions: Kisspeptin and β-hCG levels are more sensitive and specific in predicting early missed miscarriage. They represent non-invasive, early, and excellent predictors of missed miscarriage, which can be used if confirmed by further studies.
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