Association of Left Atrial Coupling Index with Infarction Site and Cardiac Biomarkers in Patients with First Episode of Acute Myocardial Infarction

Harith Imad Shwailia; Oday Jasim Al-Salihi

doi:10.54133/ajms.v10i2.2873

المؤلفون

Harith Imad Shwailia Department of Internal Medicine, Babylon Center, Merjan Teaching Hospital, Babylon, Iraq https://orcid.org/0009-0002-8291-2937
Oday Jasim Al-Salihi Department of Internal Medicine, College of Medicine, University of Babylon, Babylon, Iraq; Merjan Teaching Hospital, Babylon, Iraq

DOI:

https://doi.org/10.54133/ajms.v10i2.2873

الكلمات المفتاحية:

Acute Myocardial Infarction، Echocardiography، Left Atrial Coupling Index، NT-proBNP، Troponin

الملخص

Background: Acute myocardial infarction leads to elevation of left ventricular pressure, which is transmitted to the left atrium, resulting in changes in left atrial volume and function. LACI is a novel echocardiographic parameter that reflects the left atrioventricular interaction and may provide insight into infarction size and early risk stratification. Objectives: To evaluate LACI and its association with infarction site and cardiac biomarkers, including troponin and N-terminal pro-B-type natriuretic peptide (NT-proBNP), in patients experiencing a first episode of acute myocardial infarction. Methods: This cross-sectional study enrolled forty-two patients with the first episode of acute myocardial infarction. Peak serum troponin and NT-proBNP were recorded for each patient. Transthoracic echocardiography was performed to assess regional wall motion abnormality, left ventricular ejection fraction, and LACI, which was calculated as the ratio of left atrial end-diastolic volume to left ventricular end-diastolic volume. Results: The mean LACI was 0.46±0.13, with significantly higher LACI values observed in patients with anterior myocardial infarction compared to inferior or lateral infarctions. LACI shows a positive correlation with troponin and NT-proBNP and was inversely associated with LV ejection fraction. Higher values were noted in patients with severe regional motion abnormality, particularly akinesia. Receiver operating characteristic (ROC) analysis demonstrated a moderate discriminatory ability for identifying patients with higher levels of cardiac biomarkers. Conclusions: LACI may reflect the infarction severity and ventricular dysfunction and could serve as a useful noninvasive tool for risk stratification and assessment of hemodynamic burden.

التنزيلات

بيانات التنزيل غير متوفرة بعد.

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