اثر الايرجنين على السمية الكلوية المستحثة بواسطة السايكلوفوسفاميد في ذكور الفئرا دراسة تشمل المقارنة مع تاثير فيتامين ه
DOI:
https://doi.org/10.54133/ajms.v9i2.2316الكلمات المفتاحية:
Cyclophosphamide، Irigenin، Nephrotoxicity، Vitamin Eالملخص
الخلاصة
الخلفية: السيكلوفوسفاميد عامل ألكلة فعال ضد طيف واسع من الأورام، مع سمية كلوية كأثر جانبي. وقد أُفيد بأن الإريجينين، وهو مركب أيزوفلفونويد طبيعي معزول من جذمور نبات بيلامكاندا تشينينسيس، يمارس أنشطة مضادة للأكسدة.
الهدف: تقييم التأثيرات الوقائية المحتملة للإريجينين على السمية الكلوية المُستحثة بالسيكلوفوسفاميد لدى ذكور الجرذان.
الطريقة: قُسِّم خمسون جرذًا ذكرًا من الجرذان البيضاء سليمة ظاهريًا إلى خمس مجموعات: (مجموعة التحكم، مجموعة الحث، مجموعة الإريجينين، مجموعة الإريجينين مع السيكلوفوسفاميد، مجموعة فيتامين هـ مع السيكلوفوسفاميد). في نهاية مدة التجربة (أي في اليوم التاسع والعشرين)، تم التضحية بجميع الجرذان. تم تقييم معايير مختلفة، بما في ذلك تركيز اليوريا والكرياتينين في مصل الدم، وعلامات مضادات الأكسدة التي خفضت مستوى الجلوتاثيون، وإنزيم الجلوتاثيون بيروكسيديز، والمالونديالدهيد في متجانس أنسجة الكلى، والفحص النسيجي للكلى.
النتائج: عند إعطاء السيكلوفوسفاميد، ارتفعت مستويات المالونديالدهيد والكرياتينين واليوريا، بينما انخفضت مستوياتها عند استخدام الإريجينين كعلاج أولي. من ناحية أخرى، أظهر الجلوتاثيون وإنزيم الجلوتاثيون بيروكسيديز المختزل سلوكًا معاكسًا. بالإضافة إلى ذلك، أكد الفحص النسيجي التأثير الوقائي للكلى للإريجينين.
الخلاصة: للإريجينين تأثير وقائي ضد تلف الكلى الناجم عن السيكلوفوسفاميد من خلال تحسين العلامات البيوكيميائية ومعايير الإجهاد التأكسدي
التنزيلات
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