Acute Remote Ischemic Preconditioning Alters Autonomic Function, Corrected Left Ventricular Ejection Time, and Pulse Transit Time in Healthy Adults

Dhuha Mohammed Abd Al Sajjad; Amal Yousif Al-Yasiri; Bassam Talib Al-Gailani

المؤلفون

Dhuha Mohammed Abd Al Sajjad Department of Physiology, College of Medicine, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0009-0004-9555-589X
Amal Yousif Al-Yasiri Department of Basic Sciences, College of Dentistry, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0003-0170-3907
Bassam Talib Al-Gailani Department of Physiology, College of Medicine, Mustansiriyah University, Baghdad, Iraq

الكلمات المفتاحية:

Corrected left ventricular ejection time ، Heart rate variability ، Pulse transit time ، Remote ischemic preconditioning

الملخص

Background: Remote ischemic preconditioning (RIPC) leads to systemic protective responses via neural, hormonal, and endothelial pathways, with autonomic modulation as a key mediator. While most studies focus on heart rate variability (HRV) and arterial stiffness, limited data exist on RIPC’s acute effects on cardiac systolic timing and vascular pulse conduction. Objective: To investigate the acute effects of RIPC on autonomic function, heart rate-corrected left ventricular ejection time (cLVET), and pulse transit time (PTT) in healthy adults. Methods: Fifteen healthy young men completed RIPC and sham RNIPC protocols. RIPC involved four 5-min cycles of upper-arm cuff inflation to 230 mmHg followed by 5-min deflation; sham used 30 mmHg. Continuous ECG and digital pulse wave recordings were obtained before and after each intervention. HRV indices, PTT, PWV, and cLVET were derived from ECG-gated waveform analysis. Results: Following RIPC, mean RR interval, SD1, pNN50, high-frequency power, and SD2 increased significantly, while systolic blood pressure decreased. PTT increased significantly, with a corresponding reduction in calculated PWV. In addition, cLVET decreased significantly after RIPC. In the sham RNIPC condition, no significant changes were observed in HRV indices, PTT/PWV, or cLVET, although systolic blood pressure also declined significantly. Conclusions: Acute RIPC induced coordinated changes in autonomic and cardiovascular timing, including enhanced vagal HRV, prolonged PTT, reduced PWV, and shortened cLVET, suggesting cLVET and PTT as useful markers for short-term autonomic–cardiovascular responses in healthy adults.

التنزيلات

بيانات التنزيل غير متوفرة بعد.

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