Comparative Analysis of Renal Function and Lipid Profile in Diabetic Patients Across Gender, Age, and Glycemic Control: A Cross-sectional Study in Basrah, Iraq

Yameny AA. Diabetes mellitus overview 2024. J Biosci Appl Res. 2024;10(3):641-645. doi: 10.21608/jbaar.2024.382794. DOI: https://doi.org/10.21608/jbaar.2024.382794

Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi: 10.1016/j.diabres.2021.109119. DOI: https://doi.org/10.1016/j.diabres.2021.109119

Huang X, Wu Y, Ni Y, Xu H, He Y. Global, regional, and national burden of type 2 diabetes mellitus caused by high BMI from 1990 to 2021, and forecasts to 2045: analysis from the global burden of disease study 2021. Front Public Health. 2025;13:1515797. doi: 10.3389/fpubh.2025.1515797. DOI: https://doi.org/10.3389/fpubh.2025.1515797

Almalki WH, Khan MS. Burden of diabetes mellitus on health and economy of the Arab world: current situation and perspectives. J Public Health (Berl). 2025;1-20. doi: 10.1007/s10389-025-02448-7. DOI: https://doi.org/10.1007/s10389-025-02448-7

Mezil SA, Abed BA. Complications of diabetes mellitus. Ann Romanian Soc Cell Biol. 2021;25(3):1546-1556.

Di Marco M, Scilletta S, Miano N, Marrano N, Natalicchio A, Giorgino F, et al. Cardiovascular risk and renal injury profile in subjects with type 2 diabetes and non-albuminuric diabetic kidney disease. Cardiovasc Diabetol. 2023;22(1):344. doi: 10.1186/s12933-023-02065-2. DOI: https://doi.org/10.1186/s12933-023-02065-2

Ballena-Caicedo J, Zuzunaga-Montoya FE, Loayza-Castro JA, Vásquez-Romero LE, Tapia-Limonchi R, De Carrillo CI, et al. Global prevalence of dyslipidemias in the general adult population: a systematic review and meta-analysis. J Health Popul Nutr. 2025;44(1):308. doi: 10.1186/s41043-025-01054-3. DOI: https://doi.org/10.1186/s41043-025-01054-3

Hashempour Z, Esmaeili F, Tabatabaei-Malazy O, Mosallanejad A, Panahi G. Worldwide prevalence of dyslipidemia in diabetes: an umbrella overview of meta-analyses. Endocr Metab Immune Disord Drug Targets. 2024;24(5):1-12. doi: 10.2174/0118715303375795250521041740. DOI: https://doi.org/10.2174/0118715303375795250521041740

Vesković M, Šutulović N, Hrnčić D, Stanojlović O, Macut D, Mladenović D. The interconnection between hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease: the transition from an adipocentric to liver-centric approach. Curr Issues Mol Biol. 2023;45(11):9084-9102. doi: 10.3390/cimb45110570. DOI: https://doi.org/10.3390/cimb45110570

Pal SC, Méndez-Sánchez N. Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis. World J Gastroenterol. 2023;29(25):3999. doi: 10.3748/wjg.v29.i25.3999. DOI: https://doi.org/10.3748/wjg.v29.i25.3999

Khan AW, Jandeleit-Dahm KA. Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches. Nat Rev Cardiol. 2025. doi: 10.1038/s41569-024-01115-w. DOI: https://doi.org/10.1038/s41569-024-01115-w

Ramadhan HH, Mohammed RN. Biomarkers and the identification of kidney damage in patients with diabetes mellitus. Hilla Univ Coll J Med Sci. 2024;2(4):41-51. doi: 10.62445/2958-4515.1037. DOI: https://doi.org/10.62445/2958-4515.1037

Ullah W, Nazir A, Israr H, Hussain S, Farooq M. Assessment of serum urea and creatinine levels in diabetic patients. BioSci Rev. 2023;5(3):26-32. doi: 10.32350/BSR.53.03. DOI: https://doi.org/10.32350/BSR.53.03

Alidrisi HA, Al-Ibadi AA, Al-Saidi JS, Alsawad MA, Jameel AA, Al-Shati AW, et al. Comparative analysis of glycemic and lipid profiles in newly diagnosed males and females with type 2 diabetes mellitus. Cureus. 2023;15(12). doi: 10.7759/cureus.50101. DOI: https://doi.org/10.7759/cureus.50101

Nnakenyi ID, Nnakenyi EF, Parker EJ, Uchendu NO, Anaduaka EG, Ezeanyika LU. Relationship between glycaemic control and lipid profile in type 2 diabetes mellitus patients in a low-resource setting. Pan Afr Med J. 2022; 41:281. doi: 10.11604/pamj.2022.41.281.33802. DOI: https://doi.org/10.11604/pamj.2022.41.281.33802

Alzahrani SH, Baig M, Aashi MM, Al-Shaibi FK, Alqarni DA, Bakhamees WH. Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: a retrospective study. Diabetes Metab Syndr Obes. 2019;12:1639-1644. doi: 10.2147/DMSO.S222271. DOI: https://doi.org/10.2147/DMSO.S222271

Du T, Yuan G, Zhou X, Sun X. Sex differences in the effect of HbA1c-defined diabetes on a wide range of cardiovascular disease risk factors. Ann Med. 2016;48(1-2):34-41. doi: 10.3109/07853890.2015.1127406. DOI: https://doi.org/10.3109/07853890.2015.1127406

Alnidawi BF. Association between glycemic control and serum lipid profile in type 2 diabetic patients: glycated hemoglobin as a dual biomarker. Al-Kindy Coll Med J. 2015;11(2):10-14.

Mansour AA, Alibrahim NT, Alidrisi HA, Alhamza AH, Almomin AM, Zaboon IA, et al. Prevalence and correlation of glycemic control achievement in patients with type 2 diabetes in Iraq: a retrospective analysis of a tertiary care database over 9 years. Diabetes Metab Syndr. 2020;14(3):265-272. doi: 10.1016/j.dsx.2020.03.008. DOI: https://doi.org/10.1016/j.dsx.2020.03.008

Alidrisi HA, Reman KA, Alhubaish ES, Hussein IH, Nwayyir HA, Zaboon IA, et al. Prevalence of chronic kidney disease and associated risk factors in patients with type 2 diabetes mellitus in Basrah, Iraq: a cross-sectional study. Diabetes Epidemiol Manag. 2026;100301. doi: 10.34172/aim.31194. DOI: https://doi.org/10.1016/j.deman.2026.100301

Vergès B. Pathophysiology of diabetic dyslipidemia: where are we? Diabetologia. 2015;58(5):886-899. doi: 10.1007/s00125-015-3525-8. DOI: https://doi.org/10.1007/s00125-015-3525-8

American Diabetes Association Professional Practice Committee. Cardiovascular disease and risk management: Standards of medical care in diabetes—2024. Diabetes Care. 2024;47(Suppl 1):S190-S212. doi: 10.2337/dc24-S010. DOI: https://doi.org/10.2337/dc24-S010

Stefanovski D, Punjabi NM, Boston RC, Watanabe RM. Insulin action, glucose homeostasis, and free fatty acid metabolism: insights from a novel model. Front Endocrinol (Lausanne). 2021;12:625701. doi: 10.3389/fendo.2021.625701. DOI: https://doi.org/10.3389/fendo.2021.625701

Frühbeck G, Méndez-Giménez L, Fernández-Formoso JA, Fernández S, Rodríguez A. Regulation of adipocyte lipolysis. Nutr Res Rev. 2014;27(1):63-93. doi: 10.1017/S095442241400002X. DOI: https://doi.org/10.1017/S095442241400002X

Mir MM, Jeelani M, Alharthi MH, Rizvi SF, Sohail SK, Wani JI, et al. Unraveling the mystery of insulin resistance: from principal mechanistic insights and consequences to therapeutic interventions. Int J Mol Sci. 2025;26(6):2770. doi: 10.3390/ijms26062770. DOI: https://doi.org/10.3390/ijms26062770

Chakraborty S, Verma A, Garg R, Singh J, Verma H. Cardiometabolic risk factors associated with type 2 diabetes mellitus: a mechanistic insight. Clin Med Insights Endocrinol Diabetes. 2023;16. doi: 10.1177/11795514231220780. DOI: https://doi.org/10.1177/11795514231220780

Ginsberg HN, Packard CJ, Chapman MJ, Borén J, Aguilar-Salinas CA, Averna M, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies. Eur Heart J. 2021;42(47):4791-4806. doi: 10.1093/eurheartj/ehab551. DOI: https://doi.org/10.1093/eurheartj/ehab551

Hirano T. Pathophysiology of diabetic dyslipidemia. J Atheroscler Thromb. 2018;25(9):771-782. doi: 10.5551/jat.RV17023. DOI: https://doi.org/10.5551/jat.RV17023

Afkarian M, Sachs MC, Kestenbaum B, Hirsch IB, Tuttle KR, Himmelfarb J, et al. Kidney disease and increased mortality risk in type 2 diabetes. J Am Soc Nephrol. 2013;24(2):302-308. doi: 10.1681/ASN.2012070718. DOI: https://doi.org/10.1681/ASN.2012070718

Van Raalte DH, Bjornstad P, Cherney DZ, de Boer IH, Fioretto P, Gordin D, et al. Combination therapy for kidney disease in people with diabetes mellitus. Nat Rev Nephrol. 2024;20(7):433-446. doi: 10.1038/s41581-024-00827-z. DOI: https://doi.org/10.1038/s41581-024-00827-z

Delanaye P, Cavalier E, Stehlé T, Pottel H. Glomerular filtration rate estimation in adults: myths and promises. Nephron. 2024;148(6):408-414. doi: 10.1159/000536243. DOI: https://doi.org/10.1159/000536243

Khader NA, Kamath VG, Kamath SU, Rao IR, Prabhu AR. Kidney function estimation equations: a narrative review. Ir J Med Sci. 2025;194(2):725-743. doi: 10.1007/s11845-025-03874-y. DOI: https://doi.org/10.1007/s11845-025-03874-y

Wang Y, O Neil A, Jiao Y, Wang L, Huang J, Lan Y, et al. Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and mortality: a systematic review and meta-analysis. BMC Med. 2019;17(1):136. doi: 10.1186/s12916-019-1355-0. DOI: https://doi.org/10.1186/s12916-019-1355-0

Amani-Beni R, Darouei B, Zefreh H, Sheikhbahaei E, Sadeghi M. Effect of obesity duration and BMI trajectories on cardiovascular disease: a narrative review. Cardiol Ther. 2023;12(2):307-326. doi: 10.1007/s40119-023-00317-6. DOI: https://doi.org/10.1007/s40119-023-00317-6

Siddiqui A, Gill R, Ringor M, Dugal JK, Malhi A, Abdallah A, et al. Gender disparities in coronary artery disease: a review of factors influencing clinical outcomes. Neth Heart J. 2025. doi: 10.1007/s12471-025-01996-7. DOI: https://doi.org/10.1007/s12471-025-01996-7

Dybiec J, Szlagor M, Młynarska E, Rysz J, Franczyk B. Structural and functional changes in aging kidneys. Int J Mol Sci. 2022;23(23):15435. doi: 10.3390/ijms232315435. DOI: https://doi.org/10.3390/ijms232315435

Noronha IL, Santa-Catharina GP, Andrade L, Coelho VA, Jacob-Filho W, Elias RM. Glomerular filtration in the aging population. Front Med (Lausanne). 2022;9:769329. doi: 10.3389/fmed.2022.769329. DOI: https://doi.org/10.3389/fmed.2022.769329

Wang Q, Pang D, Wang H. Effect of overall lifestyle on mortality and cardiovascular disease death in dyslipidemia patients. BMC Cardiovasc Disord. 2023;23(1):438. doi: 10.1186/s12872-023-03450-1. DOI: https://doi.org/10.1186/s12872-023-03450-1

Andersson NW, Corn G, Dohlmann TL, Melbye M, Wohlfahrt J, Lund M. LDL-C reduction with lipid-lowering therapy for primary prevention of major vascular events among older individuals. J Am Coll Cardiol. 2023;82(14):1381-1391. doi: 10.1016/j.jacc.2023.07.027. DOI: https://doi.org/10.1016/j.jacc.2023.07.027

Hou Y, Hu Z, Jiang F, Zhao Q, Wang C, Zhang Y. Gender-specific health-adjusted life expectancy of type 2 diabetes mellitus among the rural elderly population. Int J Public Health. 2024;69:1606680. doi: 10.3389/ijph.2024.1606680. DOI: https://doi.org/10.3389/ijph.2024.1606680

Lacasse A, Nguefack HL, Page MG, Choinière M, Samb OM, Katz J, et al. Sex and gender differences in healthcare utilization trajectories: a cohort study among Quebec workers living with chronic pain. BMJ Open. 2023;13(7):e070509. doi: 10.1136/bmjopen-2022-070509. DOI: https://doi.org/10.1136/bmjopen-2022-070509