Is Maternal Aspirin Intake Truly Safe in The Long Run?
DOI:
https://doi.org/10.54133/ajms.v11i1.3155Keywords:
Low-dose aspirin, Long-term safety, Pregnancy, Preeclampsia, Recurrent pregnancy lossAbstract
N/A
Downloads
References
ACOG Committee Opinion No. 743: Low-dose aspirin use during pregnancy. Obstet Gynecol. 2018;132(1):e44-e52. doi: 10.1097/AOG.0000000000002708.
van Limburg Stirum EV, van ’t Hooft J, Landman AJ, Finken MJ, Ravelli AC, Leemhuis AG, et al. Long‐term child outcomes after prenatal aspirin exposure: A 4‐year follow‐up of a randomized controlled trial (the APRIL study). Int J Gynecol Obstet. 2026;173(1):302-311. doi: 10.1002/ijgo.70581.
Komoróczy B, Váncsa S, Váradi A, Hegyi P, Vágási V, Baradács I, et al. Optimal aspirin dosage for the prevention of pre-eclampsia and other adverse pregnancy outcomes: A systematic review and meta-analysis of randomized controlled trials. J Clin Med. 2025;14(7):2134. doi: 10.3390/jcm14072134.
Nori W, Shallal F, Zghair MA. Aspirin effect on mid luteal phase Doppler indices in patients with recurrent pregnancy loss. Int J Pharm Res. 2020;12(3):2929-2934. doi: 10.31838/ijpr/2020.12.03.413.
Hoffman MK, Goudar S, Dhaded S, Figueroa L, Mazariegos M, Krebs NF, et al. Neurodevelopment of children whose mothers were randomized to low-dose aspirin during pregnancy. Obstet Gynecol. 2024;143(4):554-61. doi: 10.1097/aog.0000000000005514.
Mozaffari S, Mousavi T, Nikfar S, Abdollahi M. Common gastrointestinal drug-drug interactions in geriatrics and the importance of careful planning. Expert Opin Drug Metab Toxicol. 2023;19(11):807-828. doi: 10.1080/17425255.2023.2273384.
Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, et al. Aspirin use to prevent pre-eclampsia and related morbidity and mortality: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;326(12):1186-1191. doi: 10.1001/jama.2021.14781.
Rodriguez-Sibaja MJ, Galvez-Rubalcava N, Hagerman-Sucar G, Alcocer-Gonzalez Camarena P, Gomez-Woodworth JR, Villalpando-Juarez MI, et al. Maternal, fetal, and neonatal serious adverse events associated with low-dose aspirin during the first trimester of pregnancy: A secondary analysis of the Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN) trial. Am J Obstet Gynecol MFM. 2025;7(11):101768. doi: 10.1016/j.ajogmf.2025.101768.
Hoffman MK. Bridging the Gaps between Aspirin Guidelines and Pregnancy Outcomes. Delaware J Public Health. 2025;11(5):38. doi: 10.32481/djph.2025.12.07.
Zhu J, Gan Y, Yang C, Gu W, Wang Y, Zhang J, et al. In utero aspirin exposure and child neurocognitive development: A propensity score‐matched analysis. BJOG. 2024;131(12):1630-1639. doi: 10.1111/1471-0528.17871.
Zhu J, Wang Y, Liu Z, Zhang J. Re-evaluating the impact of prenatal low-dose aspirin on child neurodevelopment. In: Seminars Perinatology. 2026 May 26 (p. 152256). WB Saunders. doi: 10.1016/j.semperi.2026.152256.
Landman AJ, van Limburg Stirum EV, de Boer MA, van't Hooft J, Ket JC, Leemhuis AG, et al. Long-term health and neurodevelopment in children after antenatal exposure to low-dose aspirin for the prevention of pre-eclampsia and fetal growth restriction: a systematic review of randomized controlled trials. Eur J Obstet Gynecol Reprod Biol. 2021;267:213-220. doi: 10.1016/j.ejogrb.2021.11.010.
Swift EM, Guðnadóttir SA, Haraldsdóttir EH, Hjartardóttir H, Atladóttir LÓ, Helgadóttir H, et al. Adherence to aspirin use during pregnancy among women at risk of pre-eclampsia: A cross-sectional study. Acta Obstet Gynecol Scand. 2026. doi: 10.1111/aogs.70281.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 )

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Published by Al-Rafidain University College. This is an open access journal issued under the CC BY-NC-SA 4.0 license (https://creativecommons.org/licenses/by-nc-sa/4.0/).



