Effectiveness of 577-nm Pro-Yellow Laser in Managing Inflammatory Acne: Results from a Quasi-Randomized Clinical Trial

Rusul Sahib Hussein Mohammed; Rena Raad Helmi; Monaf Faik Al-Samarraee; Haider Al-Sabak

doi:10.54133/ajms.v10i2.2880

Authors

Rusul Sahib Hussein Mohammed Department of Medicine, College of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq
Rena Raad Helmi Department of Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq
Monaf Faik Al-Samarraee Department of Family and Community Medicine, College of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq
Haider Al-Sabak College of Medicine, University of Kufa, Al-Najaf, Iraq https://orcid.org/0000-0002-4678-941X

DOI:

https://doi.org/10.54133/ajms.v10i2.2880

Keywords:

GAGS, Inflammatory acne, Pro-yellow laser , Traditional treatment

Abstract

Background: Acne has been treated with many types of lasers in recent years. It has been found that vascular laser effectively and safely reduce inflammation in acne lesions. Objective: To evaluate the efficacy and safety of a 577-nm pro-yellow laser with traditional treatment for patients with mild to moderate inflammatory acne. Methods: A quasi-randomized clinical trial study was conducted in a private dermatology clinic in Baghdad from January 2025 to January 2026 on 140 patients diagnosed with mild to moderate inflammatory acne and randomly divided into two groups: Group A (70 patients) underwent three laser treatment sessions/week, and group B (70 patients) received traditional treatment (topical, systemic, adjunctive, or a combination thereof). Both groups were assessed at the first session (baseline) and after one and six months from treatment. Results: Acne severity and inflammatory lesion count show greater reduction in group A (p<0.05). 70% of patients in group A and 48.6% in group B didn’t report any side effects. After six months, group A was more satisfied with the laser procedure than group B. The recurrence rate after six months was significantly higher in group B. The greatest predictor of successful 577 nm pro-yellow laser treatment was the baseline GAGS score reduction. Conclusions: Although traditional treatment is effective, the 577-nm pro-yellow laser is more promising, effective, and well-tolerated for mild to moderate inflammatory acne with favorable satisfaction and lower 6‑month recurrence relative to routine care.

Downloads

Download data is not yet available.

References

Hazarika N. Acne vulgaris: new evidence in pathogenesis and future modalities of treatment. J Dermatol Treatment. 2021;32(3):277-285. doi: 10.1080/09546634.2019.1654075.

Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020;10(1):5754. doi: 10.1038/s41598-020-62715-3.

Guguluș DL, Vâță D, Popescu IA, Pătrașcu AI, Halip IA, Mocanu M, et al. The epidemiology of acne in the current era: Trends and clinical implications. Cosmetics. 2025;12(3):106. doi: 10.3390/cosmetics12030106.

Najeeb A, Gaurav V, Sharma R. Comedones in dermatology. Indian J Dermatol Venereol Leprol. 2024;90(3):396-407. doi: 10.25259/IJDVL_896_2023.

Zhou C, Vempati A, Tam C, Khong J, Vasilev R, Tam K, et al. Beyond the surface: a deeper look at the psychosocial impacts of acne scarring. Clin Cosmet Investig Dermatol. 2023:731-738. doi: 10.2147/CCID.S406235.

Yang L, Gao Y, Wu H, Li Y, Li C, Li X. Efficacy and safety of intradermal botulinum toxin A for post-acne erythema: a split-face randomized controlled trial. Front Med. 2025;12. doi: 10.3389/fmed.2025.1610125.

Kalantari Y, Dadkhahfar S, Etesami I. Post‐acne erythema treatment: A systematic review of the literature. J Cosmet Dermatol. 2022;21(4):1379-1392. doi: 10.1111/jocd.14804.

Niedźwiedzka A, Micallef MP, Biazzo M, Podrini C. The role of the skin microbiome in acne: Challenges and future therapeutic opportunities. Int J Mol Sci. 2024;25(21). doi: 10.3390/ijms252111422.

Mar K, Khalid B, Maazi M, Ahmed R, Wang OJ, Khosravi-Hafshejani T. Treatment of post-inflammatory hyperpigmentation in skin of colour: a systematic review. J Cutaneous Med Surg. 2024;28(5):473-480. doi: 10.1177/12034754241265716.

Reynolds RV, Yeung H, Cheng CE, Cook-Bolden F, Desai SR, Druby KM, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2024;90(5):1006. doi: 10.1016/j.jaad.2023.12.017.

Mohamed E, Tawfik K, Elsayed I, Bölke E, Gerber P. 577-nm high-power optically pumped semiconductor laser is safe and effective in the treatment of inflammatory acne: a prospective, single-center, split-face comparative study. Eur J Med Res. 2021;26(1):103. doi: 10.1186/s40001-021-00573-z.

Hasan EF, Ahmed MH, Hraiga NM. Evaluating the clinical outcomes of using pro-yellow laser for steroid-induced rosacea: A prospective clinical study. Al-Rafidain J Med Sci. 2025;9(2):327-332. doi: 10.54133/ajms.v9i2.2445.

Aksoy Sarac G, Onder M. Evaluation of the efficacy of pro-yellow laser in the management of vascular skin disorders. J Cosmet Dermatol. 2022;21(3):1018-1022. doi: 10.1111/jocd.14162.

Jean-Pierre P, Tordjman L, Ghodasara A, Nwosu C, Nouri K. Emerging lasers and light-based therapies in the management of acne: a review. Lasers Med Sci. 2024;39(1):245. doi: 10.1007/s10103-024-04196-8.

Bae IH, Kwak JH, Na CH, Kim MS, Shin BS, Choi H. A comprehensive review of the acne grading scale in 2023. Ann Dermatol. 2024;36(2):65. doi: 10.5021/ad.23.094.

Al-Taie A, Hussein AN, Younes AA, Kassas M, Bandzhiki N. Acne vulgaris: Scoping insights towards pharmacological management and patient care prospects. J Sci Soc. 2025;52(4). doi: 10.4103/jss.jss_102_25

Kadhim S, Al-Atta D, Samarraee M. Superiority of the body roundness index over BMI in linking central adiposity with vitamin D3: A cross-sectional study in Iraqi adults. Funct Food Health Dis. 2025;15(11):783-795. doi: 10.31989/ffhd.v15i11.1798.

de Vries FMC, Meulendijks AM, Driessen RJB, van Dooren AA, Tjin EPM, van de Kerkhof PCM. The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: A systematic review and best-evidence synthesis. J Eur Acad Dermatol Venereol. 2018;32(7):1195-1203. doi: 10.1111/jdv.14881.

Demirci MA, Temiz SA, Abdelmaksoud A, Wollina U, Dursun R, Khachemoune A. Pro-yellow laser therapy in vascular and non-vascular skin disorders: A narrative review. J Cutaneous Aesthetic Surg. 2025;19(1):41-49. doi: 10.25259/JCAS_88_2024.

Ng MY, Lin T, Chen SH, Liao YW, Liu CM, Yu CC. Er:YAG laser suppresses pro-inflammatory cytokines expression and inflammasome in human periodontal ligament fibroblasts with Porphyromonas gingivalis-lipopolysaccharide stimulation. J Dent Sci. 2024;19(2):1135-1142. doi: 10.1016/j.jds.2023.12.011.

Mahajindawong B, Kumtornrut C, Asawanonda P, Kerr SJ, Chatsuwan T, Boontaveeyuwat E. Antimicrobial photodynamic therapy using sodium iron chlorophyllin against drug-resistant Cutibacterium acnes from patients with acne vulgaris. Sci Rep. 2026;16(1):5124. doi: 10.1038/s41598-025-34866-8.

Xu J, Huang S, Fu Z, Zheng W, Luo W, Zhuang N, et al. Effects of light and laser therapies on the microecosystem of sebaceous glands in acne treatment. Photodermatol Photoimmunol Photomed. 2025;41(1):e70005. doi: 10.1111/phpp.70005.

Seo DJ, Chung B. Low-energy, multi-wavelength long-pulse diode laser for post-sclerotherapy hyperpigmentation in Fitzpatrick skin type III-IV: A case series. Ann Phlebology. 2025;23(1):47-52. doi: 10.37923/phle.2025.23.1.47.

Mohamed EM, Abdel-Aleem HL, Elazab GMH, Rageh MA. Comparative efficacy and safety of 577-nm diode laser versus 1064-nm Nd: YAG laser for inflammatory acne vulgaris: a split-face randomized study. Lasers Med Sci. 2025;40(1):422. doi: 10.1007/s10103-025-04654-x.